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Moxifloxacin may be superior for CAP

Moxifloxacin (Avelox) appears to provide better clinical issues than levofloxacin (Levaquin) when treating somewhat old patients with community-acquired pneumonia (CAP).

This inquiry showed both drugs to be safe and effective for hospitalized patients, on the contrary a clinical response, including a reduction in acute signs and symptoms within 3 to 5 days, was reported in 5% more patients who received moxifloxacin, compared with levofoxacin.

"Patients were feeling better and clinicians considered more patients were either better or improved (with moxifloxacin)," said Dr Antonio Anzueto, MD professor of medicine, Department of Medicine, Health Sciences Center University of Texas, San Antonio.

"Therapy should be based upon the most effective that is available [because] in these patients we have no scope for poor clinical outcomes," he added.

The prospective, double-blind, randomized controll trial followed 394 hospitalized patients, mean age 77 in the Community-Acquired Pneumonia retrieval in the Elderly (CAPRIE) research Cure rates for moxifloxacin reached 90% for patients > age 65 and 945% for those > age 75 reparative rates for levofloxacin were 85% and 90% respectively.



No significant differences were set between the two groups in the rates of drug-related and serious adverse facts Mortality rates were also similar.

The data confirm in-vitro observations that moxifoxacin (400 mg/day) is a more efficacious antibiotic compared with levofloxacin (500 mg/day), with little difference in cost

Source: Clin Infect Dis 2006 42(1):73-81

COPYRIGHT 2006 Advanstar Communications, Inc.

COPYRIGHT 2006 Gale Group



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