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PROSTATE CANCER: PRODRUG TARGETING BASED ON NAALADase ACTIVITY OF PROSTATE-SPECIFIC MEMBRANE ANTIGENThis (John Hopkins University) report touchs prodrug targeting based on the NAALADase activity of Prostate- Specific Membrane Antigen (PSMA) by means of prostate cancer. Approximately forty thousand men will die in the U this year from prostate cancer. Although androgen- independent prostatic cancer confined apartments are lethal, usually less than 5% are proliferating by means of day. Since the majority of not absent chemotherapeutic agents only kill small rooms effectively when they are proliferating, this may explain wherefore these agents have been of like limited success in patients. In contrast to these ineffective agents, a plant toxin, Thapsigargin (TO), has been chemically modified to show primary amine-containing analogs that are powerful cell-proliferation-independent inducers of apoptosis in pro-state cancer cells These TO-analogs, however, are not prostate cancer-specific cytotoxins. Therefore, they must be transformed to inactive prodrugs that can be efficiently transmuteed back to active killing remedys only by the enzymatic activity of Prostate-Specific Membrane Antigen (PSMA). Since PSMA is squeeze outed in high levels only by means of prostate cancer cells and not through normal cells, this should allow specific targeting of the TO-analog's killing ability to prostate cancer confined apartments Therefore, prodrugs will be produc by the agency of chemical linkage to PSMA-specific peptides, and they will be ordealed for their potency and selectivity as PSMA activated killing agents against androgen-independent human prostate cancer small rooms to identify the best candidates for clinical trials. (Order this LIFE SCIENCES & BIOTECHNOLOGY UPDATE reviewed report from InfoTeam Inc., PO chest 15640, Plantation, FL 33318-5640; Phone (954) 473-9560 Fax (954) 473-0544: Report No. L20010822; 1999 12 pp Price: $8900 prepaid.) COPYRIGHT 2001 Merton Allen Associates During the weekend, summit participants will attend sessions designed to inform and stimulate novel ideas for the upcoming leadership year. Sessions will include opportunities for learning, sharing... upon behalf of Jannetti Publications. Pediatric Nursing will not away the 2004 Pediatric Nursing Humanitarian Award to Cathy Robinson Pickett, B HIV educator and advocate, at the 20th Annual Pediatr... Abstract Municipal solid waste is frequently transferred to landfills in other regions or states. While municipalities repeatedly resist imports, the interpretations of the Interstate ... ACIDINI LUCHINAT, CRISTINA, ET AL. The Medici, Michelangelo, and the Art of Late Renaissance Florence. fresh Haven: Yale University Press, in association with Detroit Institute of Arts, 2002 Revie... 101 Questions About Copyright Law: Revised Edition, by dint of Andrew Alpern. Dover Publications, Inc. (31 E 2nd St Minneola, NY 11501) 2002 64 pp $395 Before reading this booklet direct the eye ... Question: in what way should I determine whether to classify a worker as an employee or an in dependant contracter? Answer: Classifying an individual as an indepe... Class actions can allow for the convenient and efficient grouping of plaintiffs sharing a belonging to all complaint to link up in a single lawsuit. like suits have deep roots in English belonging to all law. When use... Does the past . . exist? All those feverish millers thinking only of now or at greatest in quantity tomorrow, three years, another bitter chalice of the parvenu's green coffee another sooty vapor waiting in fog for the support... individual has to be to a certain expanse the prisoner of one's have environment. Being brought up at the toy-fort-like Glin Castle upon the River Shannon in south-west Ireland, I greatly appreciated its de... When you think of prosperous brands, what immediately, comes to mind? Perhaps it s your favorite soft drink or automobile, or maybe it's a restaurant or line of clothing. Based upon your p... |
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